Definition and Calculation: Cardiac output (CO) is defined as the amount of blood the heart pumps in one minute. It is calculated using the formula:
- Stroke Volume (SV): The amount of blood ejected by the left ventricle during each heartbeat.
- Heart Rate (HR): The number of heartbeats per minute.
Factors Affecting Stroke Volume:
- Preload: The degree of stretch of the heart muscle before contraction. Higher preload increases stroke volume.
- Afterload: The resistance the heart must overcome to eject blood. Higher afterload decreases stroke volume.
- Contractility: The strength of the heart's contraction. Increased contractility increases stroke volume.
Factors Affecting Heart Rate:
- Autonomic Nervous System: The sympathetic nervous system increases heart rate, while the parasympathetic nervous system decreases it.
- Hormones: Hormones like adrenaline increase heart rate.
- Physical Activity: Exercise increases heart rate to meet the body's increased demand for oxygen.
Clinical Significance:
- Normal Values: The average cardiac output for an adult at rest is about 5 liters per minute.
- Measurement: Cardiac output can be measured using various techniques, including echocardiography and thermodilution.
- Implications: Changes in cardiac output can indicate various cardiovascular conditions. For example, low cardiac output can signal heart failure, while high cardiac output can occur in conditions like hyperthyroidism.